The minibus-sized Russian craft has been in a low orbit around Earth since losing contact with engineers shortly after its launch on November 8.
It had been intended to explore Phobos, one of Mars's two moons, but became stranded while still orbiting Earth and attempts to put it back on its original course failed.
Most of its mass is expected to burn up as the craft re-enters the atmosphere but 20 or 30 pieces of small debris collectively weighing about 200kg could reach Earth.
In a normal re-entry about 20 per cent of the space junk's mass would be likely to reach Earth, but in the case of Phobos-Grunt it could be even less because it contains large quantities of unused fuel which will burn or dissipate in the atmosphere.
In theory the remains could land anywhere south of Watford or north of the Falkland Islands, with a sea landing most likely due to the size of the oceans relative to the continents.
But scientists said observers would be unlikely to even see the debris crash to Earth unless it flew directly overhead in a clear sky, and that the chances of anyone being injured were absolutely minute.
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