The prosecution had read out parts of his confession as the trial began and accused him of killing 166 people.
Prosecutor Ujwal Nikam said this was a conspiracy hatched in Pakistan to wage war on India.
Friday's opening of the trial followed a number of procedural delays.
The latest was on Wednesday when Mr Qasab's lawyer was sacked for allegedly also signing up to defend a victim.
More than 170 people, including nine gunmen, were killed in the attacks last November.
Mr Qasab, 21, is charged with murder and waging war on India. He faces the death penalty if convicted.
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