That military assault left hundreds dead and damaged millions of dollars worth of infrastructure.
The delegation, organised by the European Campaign to End the Siege on Gaza (ECESG), is due to arrive in Egypt on Thursday, from where they will cross into Gaza.
The delegation, headed by Sir Gerald Kaufman, a veteran British MP, is the biggest in years to visit Gaza.
The parliamentarians represent 12 European countries and include Lord Ahmed, Jeremy Corbyn, Baroness Tonge and Clare Short, a former UK international development secretary.
The delegation will meet Amr Moussa, the secretary-general of the Arab League, as well as other Egyptian officials, to discuss the humanitarian condition in Gaza, in light of the continued siege imposed by Israel.
The organisation has already sent a number of boats carrying humanitarian aid for the besieged population.
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