The brewer is putting three once-in-a-lifetime experiences up for grabs themed on the colour of its famous black stout beer.
To mark its 250 years in business, the company is sending one winner into space, another to the depths of the ocean, and a third to an exclusive Black Eyed Peas concert.
A Guinness spokeswoman said: "Since 1759, Arthur Guinness and the Guinness brand have been behind some remarkable and hugely momentous achievements.
"To continue this legacy and as part of the 250 celebrations, Guinness is giving something back to supporters around the world."
The competition is open to adults in 28 countries at its website www.guinness.com until the 250-year anniversary on September 24 – dubbed Arthur's Day.
The Guinness space experience gives one person the chance to become one of the first non-professional astronauts to venture into space with Sir Richard Branson's Virgin Galactic, the world's first commercial spaceline.
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