Antibodies found that prevent HIV from causing severe AIDS
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After nearly two decades of futile searching for a vaccine against the AIDS virus, researchers are reporting the tantalizing discovery of antibodies that can prevent the virus from multiplying in the body and producing severe disease. They do not have a vaccine yet, but they may well have a road map toward the production of one.
A team based at the Scripps Research Institute in La Jolla reports today in the journal Science that they have isolated two so-called broadly neutralizing antibodies that can block the action of many strains of HIV, the virus responsible for AIDS.
Crucial to the discovery is the fact that the antibodies target a portion of HIV that researchers had not considered in their search for a vaccine. Moreover, the target is a relatively stable portion of the virus that does not participate in the extensive mutations that have made HIV able to escape from antiviral drugs and previous experimental vaccines.
(...) At least 33 million people worldwide are infected with HIV, and at least 25 million have died from AIDS, according to the World Health Organization. Two large trials of experimental vaccines have failed -- the most recent, in 2007, because the vaccine apparently made people more susceptible to infection.
To find the neutralizing antibodies, researchers collected blood samples from more than 1,800 people in Thailand, Australia and Africa who had been infected with HIV for at least three years without the infection proceeding to severe disease. Such individuals are most likely to produce antibodies that interfere with the replication of the virus.
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Crucial to the discovery is the fact that the antibodies target a portion of HIV that researchers had not considered in their search for a vaccine. Moreover, the target is a relatively stable portion of the virus that does not participate in the extensive mutations that have made HIV able to escape from antiviral drugs and previous experimental vaccines.
(...) At least 33 million people worldwide are infected with HIV, and at least 25 million have died from AIDS, according to the World Health Organization. Two large trials of experimental vaccines have failed -- the most recent, in 2007, because the vaccine apparently made people more susceptible to infection.
To find the neutralizing antibodies, researchers collected blood samples from more than 1,800 people in Thailand, Australia and Africa who had been infected with HIV for at least three years without the infection proceeding to severe disease. Such individuals are most likely to produce antibodies that interfere with the replication of the virus.
Read more...